Open AccessTelmisartan and Amlodipine Single‐Pill Combinations vs Amlodipine Monotherapy for Superior Blood Pressure Lowering and Improved Tolerability in Patients With Uncontrolled Hypertension: Results of the TEAMSTA‐5 Study
Author(s) -
Neldam Steen,
Lang Margreet,
Jones Russell
Publication year - 2011
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2011.00468.x
Subject(s) - medicine , amlodipine , tolerability , blood pressure , pill , telmisartan , cardiology , pharmacology , adverse effect
J Clin Hypertens (Greenwich). 2011;13:459–466. ©2011 Wiley Periodicals, Inc. An 8‐week, randomized, double‐blind, controlled study with single‐pill combinations of telmisartan 40 mg or 80 mg/amlodipine 5 mg (T40/A5 or T80/A5) vs monotherapy with amlodipine 5 mg or 10 mg (A10) in 1097 patients with uncontrolled hypertension (diastolic blood pressure [BP] ≥90 mm Hg). T40/A5 and T80/A5 resulted in significantly greater ( P <.0001) reductions in seated trough systolic/diastolic BP vs A5 (−7.4 mm Hg/−3.6 mm Hg; −8.8 mm Hg/−4.9 mm Hg) and a significantly greater ( P <.001) proportion of patients achieving systolic/diastolic BP goal rate (60.0%/56.7%; 65.7%/63.8%) vs A5 (39.2%/42.0%). Superior BP reductions were also seen with T40‐T80/A5 vs A10, with BP goal rates at least as high as with A10; however, there was significantly more peripheral edema with A10 (27.2% vs 4.3% for pooled T40‐T80/A5; P <.0001). Switching patients with uncontrolled BP to a single‐pill combination of T40/A5 or T80/A5 is a better treatment option than up‐titration to full‐dose monotherapy with A10.