Improvements in Insulin Sensitivity and Muscle Blood Flow in Aerobic‐Trained Overweight‐Obese Hypertensive Patients Are Not Associated With Ambulatory Blood Pressure

To verify whether there are relationships between vascular and hormonal responses to aerobic training in hypertensive persons, sedentary hypertensive patients were randomized to an aerobic training or a callisthenic exercise group. The patients’ 24‐hour blood pressure, arterial compliance, forearm blood flow, and hormonal profile were evaluated at baseline and after 3‐month training protocols. Mean maximal oxygen consumption (VO 2 max) increased by 8% in the aerobic group ( P <.001), while no change was observed in the control group. There was a decrease in insulin resistance (homeostatic model assessment of insulin resistance, P =.039) and plasma cortisol ( P =.006) in the aerobic group only, that also demonstrated an increase in forearm blood flow ( P <.001) after training. No relationship was observed between change in blood pressure or change in body mass and other parameters. Aerobic training can promote a decrease in cardiovascular risk in hypertensive adults by improving vascular function and insulin resistance, despite no changes in ambulatory blood pressure after a 3‐month intervention. J Clin Hypertens (Greenwich). 2011;13:89–96. © 2010 Wiley Periodicals, Inc.