Open AccessEffects of Pioglitazone and Metformin Fixed‐Dose Combination Therapy on Cardiovascular Risk Markers of Inflammation and Lipid Profile Compared With Pioglitazone and Metformin Monotherapy in Patients With Type 2 Diabetes
Author(s) -
Perez Alfonso,
Jacks Randal,
Arora Vipin,
Spanheimer Robert
Publication year - 2010
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2010.00389.x
Subject(s) - pioglitazone , metformin , medicine , type 2 diabetes , diabetes mellitus , type 2 diabetes mellitus , endocrinology , pharmacology , gastroenterology
J Clin Hypertens (Greenwich). Type 2 diabetes mellitus (T2DM) treatment should not increase cardiovascular (CV) risk and at best could provide benefit beyond lowering glucose. Pioglitazone has demonstrated a favorable CV profile relative to other oral antidiabetic drugs (OADs) in outcome and observational studies. This randomized, double‐blind, parallel‐group controlled study examined circulating biomarkers of CV risk in T2DM patients receiving a fixed‐dose combination (FDC) of pioglitazone/metformin compared with the respective monotherapies. Patients with stable glycosylated hemoglobin (HbA 1c ) for 3 months taking no OADs were treated with pioglitazone 15 mg/metformin 850 mg FDC twice daily (bid), pioglitazone 15 mg bid, or metformin 850 mg bid for 24 weeks. FDC and pioglitazone increased high‐density lipoprotein cholesterol by 14.20% and 9.88%, respectively, vs an increase of 6.09% with metformin (P<.05, metformin vs FDC). Triglycerides decreased with all three treatments −5.95%, −5.54% and −1.78%, respectively; P=not significant). FDC and pioglitazone significantly decreased small low‐density lipoprotein and increased large low‐density lipoprotein particle concentrations. Reductions in high‐sensitivity C‐reactive protein were greater in the FDC and pioglitazone groups. Increases in adiponectin were significant in the FDC and pioglitazone groups (P<.0001 vs metformin). Overall, adverse events were not higher with the FDC. Thus, treatment with the FDC resulted in improved levels of CV biomarkers, which were better than or equal to monotherapy. J Clin Hypertens (Greenwich). 2010;12:973–982. © 2010 Wiley Periodicals, Inc.