Open AccessAngiotensin II Subtype 2 Receptor: Potential Therapy
Author(s) -
Siragy Helmy M.
Publication year - 2009
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2009.00212.x
Subject(s) - medicine , angiotensin ii , agonist , receptor , nitric oxide , angiotensin receptor , endocrinology , inflammation , pharmacology
The angiotensin II type 2 (AT 2 R) receptor is highly expressed during fetal development but rapidly declines with aging and is limited to certain organs. However, this receptor is reexpressed in response stress or injury. AT 2 R is believed to play a protective role by counteracting the effects of the angiotensin II type 1 receptor. AT 2 R enhances vasodilation, renal sodium excretion, and nitric oxide production. AT 2 R also has antiproliferation, antihypertrophy, and anti‐inflammation effects. The role of AT 2 R in human health and disease is not well established yet, mainly due to the lack of tools to manipulate this receptor. With the recent development of an AT 2 R nonpeptide agonist, the function of this receptor and its role in disease management is being investigated.