Open AccessEscalating Antihypertensive Medications in End‐Stage Renal Disease Patients Does Not Improve Blood Pressure Control
Author(s) -
Tapolyai Mihály,
Karim Jariatul,
Fakhruddin Atif
Publication year - 2008
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2008.07198.x
Subject(s) - medicine , blood pressure , end stage renal disease , hemodialysis , population , cardiology , environmental health
The authors examined the efficacy of antihypertensive medication use in end‐stage renal disease (ESRD). They compared achieved blood pressures (BPs) in a cross‐sectional study of 106 ESRD patients whose medications had not been changed for at least 2 months. Group 1 (n=36) included patients who took 0 or 1 medication; group 2 (n=56), 2 or 3 medications; and group 3 (n=14), ≥4 medications. The population's mean age was 55.1 years, 87% were African American, and 57% were men weighing 76.9 kg who were on 229 minutes of hemodialysis with an edKt/V of 1.35; there was no difference between the 3 groups. The authors found a difference in the mean BPs: 139/72 mm Hg in group 1, 154/82 mm Hg in group 2, and 165/91 mm Hg in group 3 ( P =.01 for systolic, P =.002 for diastolic), with a mean arterial pressure difference of 94.4, 106.4, and 115.4 mm Hg ( P =.002). The authors conclude that in this group of primarily African American patients, the control of hypertension in ESRD is not achieved by escalating the number of antihypertensive medications . J Clin Hypertens (Greenwich). 2008;10:215–218 .