Open AccessStatins for Primary Prevention of Cardiovascular Mortality in Women: A Systematic Review and Meta‐Analysis
Author(s) -
Bukkapatnam Radhika N.,
Gabler Nicole B.,
Lewis William R.
Publication year - 2010
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1751-7141.2009.00059.x
Subject(s) - medicine , meta analysis , primary prevention , hydroxymethylglutaryl coa reductase inhibitors , statin , disease
The benefits of statins on prevention of coronary heart disease in women without heart disease have not been clarified. The authors systematically reviewed all the published literature on primary prevention trials and found 6 primary prevention trials to date with sex‐specific data on mortality and coronary heart disease events in women. The summary risk ratio for primary prevention of all‐cause mortality was 0.90 (95% confidence interval, 0.60–1.35; P=.61) and for any coronary heart disease event was 0.78 (95% confidence interval, 0.64–0.96; P=.02). This review reveals that statin therapy along with diet and exercise in moderately hyperlipidemic women without a previous history of cardiovascular disease is of significant benefit in preventing coronary heart disease events but of no proven benefit in preventing all‐cause mortality. Prev Cardiol. 2010;13:84–90. © 2009 Wiley Periodicals, Inc.