Open AccessElevated Levels of Homocysteine Predict Cardiovascular Death, Nonfatal Myocardial Infarction, and Symptomatic Bypass Graft Disease at 2‐Year Follow‐Up Following Coronary Artery Bypass Surgery
Author(s) -
Shammas Nicolas W.,
Dippel Eric J.,
Jerin Michael,
Toth Peter P.,
Kapalis Matthew,
Reddy Mythri,
Harb Harb
Publication year - 2008
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1751-7141.2008.08293.x
Subject(s) - medicine , cardiology , myocardial infarction , homocysteine , ejection fraction , coronary artery disease , body mass index , diabetes mellitus , coronary artery bypass surgery , univariate analysis , bypass surgery , surgery , artery , multivariate analysis , heart failure , endocrinology
Severe graft disease occurs in patients at a rate of approximately 15% within the first year of coronary artery bypass grafting (CABG). In this study, the authors examined predictors of the combined end point of death, nonfatal myocardial infarction (MI), and bypass graft disease at 2‐year follow‐up after CABG. One hundred twenty‐one consecutive patients were included in this study after informed consent was obtained. In univariate analysis, there was a significantly ( P <.05) higher homocysteine level (11.0 ng/mol vs 9.7 ng/mol, P =.04) in patients who met the combined end point vs those who did not. There were no statistically significant differences in the following: low‐density lipoprotein cholesterol, high‐sensitivity C‐reactive protein, and lipoprotein(a) values; age; body mass index; smoking and diabetes status; statin or aspirin use; creatinine level; hematologic markers; left ventricular ejection fraction; number of bypass grafts; and distribution of coronary artery disease. Logistic regression analysis modeling for low‐density lipoprotein cholesterol, lipoprotein(a), fibrinogen, and homocysteine showed that homocysteine value ( P =.016) was an independent predictor of the primary combined end point.