Open AccessAssociation of Total Cholesterol/High‐Density Lipoprotein Cholesterol Ratio With Proximal Coronary Atherosclerosis Detected by Multislice Computed Tomography
Author(s) -
Nair Deepu,
Carrigan Thomas P.,
Curtin Ronan J.,
Popovic Zoran B.,
Kuzmiak Stacie,
Schoenhagen Paul,
Flamm Scott D.,
Desai Milind Y.
Publication year - 2009
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1751-7141.2008.00011.x
Subject(s) - medicine , multislice computed tomography , coronary atherosclerosis , cholesterol , multislice , computed tomography , cardiology , total cholesterol , radiology , coronary heart disease
The authors assessed the association between an elevated total cholesterol to high‐density lipoprotein cholesterol (TC/HDL‐C) ratio (≥4) and proximal coronary artery disease (CAD), as observed on multislice computed tomography. Coronary multislice computed tomographic angiography (96% on 40‐ or 64‐slice) was performed in 295 individuals (39% women; mean age, 54±13 years) without documented CAD who were referred for coronary evaluation. Significant CAD was defined as ≥50% stenosis in the left main, proximal left anterior descending, or ≥2 epicardial vessels. Proximal plaque was defined as presence of any plaque in left main or proximal left anterior descending vessels. Individuals with an elevated TC/HDL‐C ratio vs those without had a higher prevalence of proximal plaque (62% vs 48%, P =.04) and significant CAD (19% vs 9%, P =.009). On multivariate logistic regression analysis, only age, sex, and TC/HDL‐C ratio ≥4 were associated with significant CAD and proximal plaque.