Open AccessSerum Carbohydrate Antigen 125 Levels in Nonischemic Dilated Cardiomyopathy: A Useful Biomarker for Prognosis and Functional Mitral Regurgitation
Author(s) -
Karaca Oguz,
Guler Gamze B.,
Guler Ekrem,
Gunes H. Murat,
Alizade Elnur,
Agus Hicaz Z.,
Gol Gokhan,
Kahveci Gokhan,
Esen Ozlem,
Esen A. Metin,
Turkmen Muhsin
Publication year - 2011
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1751-7133.2011.00260.x
Subject(s) - medicine , cardiology , ejection fraction , natriuretic peptide , heart failure , biomarker , dilated cardiomyopathy , pulmonary artery , mitral regurgitation , receiver operating characteristic , functional mitral regurgitation , biochemistry , chemistry
The authors investigated the prognostic relevance of serum carbohydrate antigen 125 (CA125) levels in nonischemic dilated cardiomyopathy (NICMP) and assessed whether increased levels relate to the degree of functional mitral regurgitation (FMR). Seventy‐seven patients with NICMP were enrolled and followed‐up for 10±2 months in this prospective study. Receiver‐operating characteristic analysis established a cutoff CA125 value of 25 U/mL for predicting mortality. Patients were divided into two groups according to their CA125 levels (CA125 <25 U/mL [n=58] and CA125 ≥25 U/mL [n=19]). Patients with high CA125 values had statistically worse functional status, higher B‐type natriuretic peptide (BNP) levels, higher left ventricular volumes, lower ejection fraction, higher E /Em ratio, higher pulmonary artery systolic pressure, and more severe FMR. On the multivariate analysis, serum CA125 (P=.002) and severe FMR (P=.04) were identified as the independent predictors of mortality. Serum CA125 levels also correlated with BNP levels and FMR severity (P<.001). Serum CA125 is a powerful prognostic biomarker that is associated with the severity of heart failure, serum BNP levels and several echocardiographic parameters including left ventricular volumes, systolic and diastolic functions, pulmonary artery pressure, and the degree of FMR. Serum CA125 was also shown as an independent predictor of mortality during 10±2 months of follow‐up. ©2011 Wiley Periodicals, Inc.