Open AccessHydrogels as a Platform for Stem Cell Delivery to the Heart
Author(s) -
Kurdi Mazen,
Chidiac Rony,
Hoemann Caroline,
Zouein Fouad,
Zgheib Carlos,
Booz George W.
Publication year - 2010
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1751-7133.2010.00145.x
Subject(s) - self healing hydrogels , medicine , stem cell , paracrine signalling , stem cell therapy , heart failure , neuroscience , cardiology , mesenchymal stem cell , microbiology and biotechnology , pathology , biology , receptor , chemical engineering , engineering
Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here the authors discuss chitosan‐based hydrogels. Congest Heart Fail. 2010;16:132–135. © 2010 Wiley Periodicals, Inc.