Open AccessStatin Use Is Associated With Improved Survival in Patients With Advanced Heart Failure Receiving Resynchronization Therapy
Author(s) -
Sumner Andrew D.,
Boehmer John P.,
Saxon Leslie A.,
Carson Peter,
Feldman Arthur M.,
Galle Elizabeth,
Bristow Michael R.
Publication year - 2009
Publication title -
congestive heart failure
Language(s) - English
Resource type - Journals
eISSN - 1751-7133
pISSN - 1527-5299
DOI - 10.1111/j.1751-7133.2009.00057.x
Subject(s) - medicine , cardiac resynchronization therapy , hazard ratio , heart failure , statin , cardiology , defibrillation , confidence interval , proportional hazards model , ejection fraction
It is unknown whether statin use improves survival in patients with advanced chronic heart failure (HF) receiving cardiac resynchronization therapy (CRT). The authors retrospectively assessed the effect of statin use on survival in patients with advanced chronic HF receiving CRT alone (CRT‐P) or CRT with implantable cardioverter‐defibrillator therapy (CRT‐D) in 1520 patients with advanced chronic HF from the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) trial database. Six hundred three patients (40%) were taking statins at baseline. All‐cause mortality was 18% in the statin group and 22% in the no statin group (hazard ratio [HR] 0.85; confidence interval (CI), 0.67–1.07; P =.15). In a multivariable analysis controlling for significant baseline characteristics and use of CRT‐P/CRT‐D, statin use was associated with a 23% relative risk reduction in mortality (HR, 0.77; CI, 0.61–0.97; P =.03). Statin use is associated with improved survival in patients with advanced chronic HF receiving CRT. No survival benefit was seen in patients receiving statins and optimal pharmacologic therapy without CRT.