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The spectrum of T‐cell and natural killer/T‐cell neoplasms with leukaemic presentation in a single institution in Taiwan
Author(s) -
CHANG S.T.,
HSIEH Y.C.,
KUO S.Y.,
LU C.L.,
CHU J.S.,
CHUANG S.S.
Publication year - 2012
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2012.01407.x
Subject(s) - lymphoma , t cell lymphoma , medicine , peripheral t cell lymphoma , natural killer cell , t cell , cell , prolymphocytic leukemia , immunology , pathology , leukemia , biology , cytotoxic t cell , chronic lymphocytic leukemia , immune system , biochemistry , genetics , in vitro
Summary T cell and natural killer (NK)/T‐cell neoplasms are rare and may occasionally present as leukaemia. We retrospectively searched T cell and NK/T‐cell tumours in a single institution in Taiwan from January 2000 to December 2009 and identified 137 (19.1%) patients with T cell and NK/T‐cell tumours among 718 patients with lymphoid neoplasms. Among these 137 patients, 18 (13.1%) presented with leukaemia including T‐lymphoblastic lymphoma/leukaemia (T‐LBL), T‐cell prolymphocytic leukaemia, aggressive NK‐cell leukaemia, adult T‐cell lymphoma/leukaemia (ATLL), T‐cell large granular lymphocytic (T‐LGL) leukaemia and unspecified peripheral T‐cell lymphoma. Cases with concurrent lymphoma, higher absolute leukaemic cell counts and elevated lactate dehydrogenase level carried a poorer prognosis. The survival was dichotomous, with a very poor prognosis for patients with T‐LBL, T‐cell prolymphocytic leukaemia, aggressive NK‐cell leukaemia, ATLL in acute phase and unspecified peripheral T‐cell lymphoma, while those with T‐LGL leukaemia and ATLL in chronic phase had a favourable outcome.