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ICSH recommendations for the measurement of Haemoglobin F
Author(s) -
STEPHENS A. D.,
ANGASTINIOTIS M.,
BAYSAL E.,
CHAN V.,
DAVIS B.,
FUCHAROEN S.,
GIORDANO P. C.,
HOYER J. D.,
MOSCA A.,
WILD B.
Publication year - 2012
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2011.01367.x
Subject(s) - fetal hemoglobin , red cell , capillary electrophoresis , medicine , disease , fetus , biology , pathology , chromatography , chemistry , pregnancy , genetics
Summary Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto‐maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high‐performance liquid chromatography and capillary electrophoresis.