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Interleukin‐10 gene polymorphism reflects the severity of chronic immune thrombocytopenia in Japanese patients
Author(s) -
SAITOH T.,
KASAMATSU T.,
INOUE M.,
MITSUI T.,
KOISO H.,
YOKOHAMA A.,
HANDA H.,
MATSUSHIMA T.,
TSUKAMOTO N.,
KARASAWA M.,
OGAWARA H.,
NOJIMA Y.,
MURAKAMI H.
Publication year - 2011
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2011.01320.x
Subject(s) - haplotype , genotype , immune system , immunology , platelet , medicine , polymorphism (computer science) , single nucleotide polymorphism , gene polymorphism , gastroenterology , gene , biology , genetics
Summary Introduction: T‐helper cell type 1 (Th1) polarization of the immune response has been documented in patients with chronic immune thrombocytopenia (ITP). Interleukin (IL)‐10 is the most important factor regulating Th1 and T‐helper type 2 cytokine synthesis. This study evaluated the impact of IL‐10 polymorphisms on both susceptibility to, and severity of, chronic ITP. Methods: We analyzed ‐1082(G/A), ‐812(C/T), and ‐592(C/A) IL‐10 polymorphisms in 90 patients with adult chronic ITP and 202 race‐ and sex‐matched healthy controls. Results: No significant differences in the genotype or haplotype frequencies were observed between the patient with chronic ITP and the control group. However, more patients with the ‐592AA genotype showed a severe thrombocytopenic state (platelet count <10 × 10 9 /l) than those with the ‐592CC/CA genotypes (44.1% vs. 19.6%, P = 0.01). Furthermore, more patients with the ATA/ATA haplotype showed a severe thrombocytopenic state than those without the ATA/ATA haplotype (44.1% vs. 19.6%, P = 0.01). Conclusion: According to our data, patients with low producer type of IL‐10 polymorphisms have more severe thrombocytopenia, suggesting that IL‐10 gene polymorphisms may reflect the severity of ITP.