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Frequency and distribution of Epstein–Barr virus infection and its association with P53 expression in a series of primary nodal non‐Hodgkin lymphoma patients from South India
Author(s) -
SASIKALA P. S.,
NIRMALA K.,
SUNDERSINGH S.,
MAHJI U.,
RAJKUMAR T.
Publication year - 2010
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2008.01125.x
Subject(s) - series (stratigraphy) , hodgkin lymphoma , lymphoma , epstein–barr virus , nodal , virus , expression (computer science) , medicine , virology , oncology , pathology , biology , paleontology , computer science , programming language
Summary This study investigated the prevalence of Epstein–Barr virus (EBV) infection and its association with P53 expression in a panel of 87 previously untreated nodal non‐Hodgkin lymphomas (NHLs) from India. Polymerase chain reaction specific for Epstein Barr nuclear antigen 1 (EBNA1) and EBNA‐3C was performed on the lymphnode tissue DNA, while P53 expression was analyzed by immunohistochemistry. EBV, predominantly type A strain, was detected in 27/87 (31%) nodal lymphoid malignancies, 11/46 diffuse large B‐cell lymphomas, 6/17 follicular lymphoma, 4/6 anaplastic large cell lymphomas (ALCL), 5/11 peripheral T‐cell lymphomas (PTCL) and 1/7 lymphoblastic lymphomas. EBV infection was more frequently observed in a specific subset of nodal NHL, suggesting a causative role of EBV infection in the pathogenesis of ALCL and PTCL. There was no significant association between EBV and P53 expression in our series of NHL patients.