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Preservation of basophils in dapsone‐induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases
Author(s) -
BESSER M.,
VERA J.,
CLARK J.,
CHITNAVIS D.,
BEATTY C.,
VASSILIOU G.
Publication year - 2009
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2007.00983.x
Subject(s) - dapsone , peroxidase , immunology , pathogenesis , eosinophil peroxidase , function (biology) , medicine , chemistry , biology , myeloperoxidase , enzyme , inflammation , biochemistry , microbiology and biotechnology
Summary We describe a hitherto unreported laboratory observation, namely the selective preservation of basophils, in a case of severe dapsone‐induced agranulocytosis. Dapsone is known to be metabolised by peroxidases to nitroso derivatives in non‐hemopoietic cells where these can in turn act as haptens. Our observation that basophils are selectively spared in this syndrome supports the hypothesis that leucocyte peroxidases function in a similar way to facilitate the pathogenesis of this form of agranulocytosis in susceptible individuals.