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Molecular genetic analysis of haematological malignancies II: mature lymphoid neoplasms
Author(s) -
BENCH A. J.,
ERBER W. N.,
FOLLOWS G. A.,
SCOTT M. A.
Publication year - 2007
Publication title -
international journal of laboratory hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.705
H-Index - 55
eISSN - 1751-553X
pISSN - 1751-5521
DOI - 10.1111/j.1751-553x.2007.00876.x
Subject(s) - minimal residual disease , molecular diagnostics , gene rearrangement , molecular genetics , biology , disease , gene , computational biology , pathology , medicine , bioinformatics , immunology , genetics , leukemia
Summary Molecular genetic techniques have become an integral part of the diagnostic assessment for many lymphomas and other chronic lymphoid neoplasms. The demonstration of a clonal immunoglobulin or T cell receptor gene rearrangement offers a useful diagnostic tool in cases where the diagnosis is equivocal. Molecular genetic detection of other genomic rearrangements may not only assist with the diagnosis but can also provide important prognostic information. Many of these rearrangements can act as molecular markers for the detection of low levels of residual disease. In this review, we discuss the applications of molecular genetic analysis to the chronic lymphoid malignancies. The review concentrates on those disorders for which molecular genetic analysis can offer diagnostic and/or prognostic information.