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Distribution of hepatitis C virus genotypes in C hinese patients with chronic hepatitis C : Correlation with patients’ characteristics and clinical parameters
Author(s) -
Dong Zhi Xia,
Zhou Hui Juan,
Wang Jian Hua,
Xiang Xiao Gang,
Zhuang Yan,
Guo Si Min,
Gui Hong Lian,
Zhao Gang De,
Tang Wei Liang,
Wang Hui,
Xie Qing
Publication year - 2012
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2012.00636.x
Subject(s) - medicine , genotype , hepatitis c virus , virology , hepatitis c , hepatitis a virus , correlation , immunology , virus , biology , gene , genetics , geometry , mathematics
Objective This study aimed to explore the most up‐to‐date distribution of hepatitis C virus ( HCV) genotypes in C hina, especially the association between HCV genotypes and patients’ characteristics and clinical parameters. Methods Sera from 483 HCV antibody‐positive patients were genotyped using a HCV genotyping chip assay. The distribution of HCV genotypes, clinical parameters, modes of transmission and duration of infection were determined and the relationships among these parameters were analyzed. Results A total of 424 patients were successfully genotyped. HCV genotypes 1, 2, 3 and 6 were found with a constituent ratio of 72.1%, 12.3%, 10.6% and 5.0%, respectively, in which subtypes 1b (69.1%), 2a (11.6%) and 3a (7.5%) were prevalent. The mean age of patients with genotype 1 and 2 was significantly elder than those with genotype 3 and 6 ( P < 0.05). The distribution of HCV genotypes in relation to the mode of HCV transmission was remarkable ( P < 0.001). Transfusion of blood and blood products was the main mode of transmission. Most genotype 1 infection (53.1%) was found in the group with a duration of HCV infection of 10–20 years. Genotype 1b was independently associated with age ( P = 0.001) and mode of HCV transmission ( P = 0.007). Conclusions The main HCV subtype was genotype 1b in C hinese patients. The prevalence of HCV genotypes was correlated with age and the mode of HCV transmission. Genotype 3a and 6 may become an increasing threat in the future.