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Change of mucosal color in early gastric cancer
Author(s) -
Lee Hak Hyun,
Lee SunYoung,
Yoon Hyeon Young,
Hong Sung Noh,
Kim Jeong Hwan,
Sung InKyung,
Park Hyung Seok,
Shim Chan Sup,
Han Hye Seung
Publication year - 2012
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2012.00620.x
Subject(s) - medicine , signet ring cell carcinoma , gastroenterology , cancer , gastric carcinoma , carcinoma , pathology , adenocarcinoma
Objective: To investigate the association between mucosal color change and the characteristics of early gastric cancer ( EGC ). Methods: Data of consecutive patients with EGC resected between August 2005 and October 2010 at K onkuk U niversity M edical C enter were analyzed retrospectively. The characteristics of EGC relative to mucosal color change were analyzed. Results: Whitish discoloration of the cancer was linked to female to male gender ratio ( P = 0.009), large tumor size ( P < 0.001), deep invasion ( P = 0.046) and depressed contours ( P < 0.001) compared with EGC without discoloration or with hyperemic change. In addition, a whitish discoloration was also related to signet ring cell carcinoma ( P < 0.001) and diffuse type carcinoma based on Lauren's classification ( P < 0.001). On multiple linear regression analysis, diffuse type based on Lauren's classification ( P = 0.017) and depth of invasion ( P = 0.003) were significant independent factors for whitish discoloration. Conclusions: Mucosal color change is an important clue in the diagnosis of EGC . EGC with whitish discoloration needs more attention due to its link with the diffuse type of Lauren's classification.