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Is obesity an indicator of complications and mortality in acute pancreatitis? An updated meta‐analysis
Author(s) -
CHEN Su Mei,
XIONG Guang Su,
WU Shu Ming
Publication year - 2012
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2012.00587.x
Subject(s) - medicine , acute pancreatitis , confidence interval , relative risk , meta analysis , obesity , pancreatitis , complication , risk factor , gastroenterology , surgery
OBJECTIVE: To provide a meta‐analyisis on whether obesity could be a prognostic indicator on the severity, development of complications and mortality of acute pancreatitis (AP). METHODS: Eligible articles were retrieved using electronic databases. Clinical studies evaluating the association between obesity and disease course of patients with AP were included. Weighted mean difference (WMD) and 95% confidence interval (CI) were estimated and pooled using RevMan 4.2.8. RESULTS: In all, 12 clinical studies with a total of 1483 patients were included in the analysis. Obese patients had a significantly increased risk of severe acute pancreatitis (SAP; RR = 2.20, 95% CI 1.82–2.66, P < 0.05), local complication (RR = 2.68, 95% CI 2.09–3.43, P < 0.05), systemic complication (RR = 2.14, 95% CI 1.42–3.21, P < 0.05) and in‐hospital mortality (RR = 2.59, 95% CI 1.66–4.03, P < 0.05) compared with non‐obese patients. CONCLUSIONS: Obesity is a definite risk factor of morbidity and in‐hospital mortality for AP and may serve as a prognostic indicator.