Premium
Lansoprazole‐based sequential and concomitant therapy for the first‐line Helicobacter pylori eradication
Author(s) -
HUANG YaoKang,
WU MengChieh,
WANG Sophie SW,
KUO ChaoHung,
LEE YiChern,
CHANG LingLi,
WANG TsungHsi,
CHEN YenHsu,
WANG WenMing,
WU DengChyang,
KUO FuChen
Publication year - 2012
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2012.00575.x
Subject(s) - lansoprazole , concomitant , medicine , helicobacter pylori , urea breath test , gastroenterology , metronidazole , clarithromycin , amoxicillin , combination therapy , rabeprazole , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology
OBJECTIVE: The aim of this prospective study was to compare the efficacy of the first‐line lansoprazole‐based sequential therapy and concomitant therapy (lansoprazole, amoxicillin, clarithromycin and metronidazole) for Helicobacter pylori (H. pylori) eradication. METHODS: A total of 169 patients with H. pylori infection were randomly assigned to either the sequential therapy group ( n = 85) or the concomitant therapy group ( n = 84). A follow‐up endoscopy or urea breath test was examined at least 12 weeks after eradication. RESULTS: Comparable H. pylori eradication rate was observed in both the sequential therapy and concomitant therapy groups by either intention‐to‐treat analysis [sequential 80.0% (68/85) vs concomitant 88.1% (74/84); P = 0.27] or per protocol analysis [sequential, 85.3% (64/75) vs concomitant, 94.6% (70/74); P = 0.60]. Adverse effects were reported and good compliance was observed in both groups ( P = 0.72). Although dual antibiotics resistance affected the therapeutic efficacy of sequential therapy ( P = 0.03), not concomitant therapy ( P = 0.74), it was not an independent factor for predicting the treatment outcome. CONCLUSION: First‐line lansoprazole‐based sequential and concomitant therapy were well‐tolerated and comparable in terms of their H. pylori eradication rate.