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Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis
Author(s) -
ITO Tetsuhide,
NAKAMURA Taichi,
FUJIMORI Nao,
NIINA Yusuke,
IGARASHI Hisato,
OONO Takamasa,
UCHIDA Masahiko,
KAWABE Ken,
TAKAYANAGI Ryoichi,
NISHIMORI Isao,
OTSUKI Makoto,
SHIMOSEGAWA Tooru
Publication year - 2011
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2011.00498.x
Subject(s) - medicine , diabetes mellitus , pancreatitis , gastroenterology , autoimmune pancreatitis , hypoglycemia , group b , endocrinology , glycated hemoglobin , triglyceride , group a , cholesterol , type 2 diabetes
OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A ( n = 35), those who developed DM and AIP simultaneously were labeled group B ( n = 58) and those who developed DM after steroid therapy for AIP were labeled group C ( n = 9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl‐tyrosyl para‐aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP‐associated pancreatic diabetes were clarified. AIP‐associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.