Premium
Meta‐analysis: The efficacy and safety of monoclonal antibody targeted to epidermal growth factor receptor in the treatment of patients with metastatic colorectal cancer
Author(s) -
NIE Fang,
SHEN Jun,
TONG Jin Lu,
XU Xi Tao,
ZHU Ming Ming,
RAN Zhi Hua
Publication year - 2009
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2009.00393.x
Subject(s) - medicine , monoclonal antibody , adverse effect , regimen , colorectal cancer , epidermal growth factor receptor , oncology , monoclonal , incidence (geometry) , panitumumab , antibody , cancer , gastroenterology , cetuximab , immunology , physics , optics
OBJECTIVE: To evaluate systematically the efficacy and safety of anti‐epidermal growth factor receptor (EGFR) monoclonal antibody added to a chemotherapeutic regimen in the treatment of patients with metastatic colorectal cancer (mCRC). METHODS: Eligible articles were identified by searching electronic databases. All randomized trials comparing the arm with an anti‐EGFR monoclonal antibody to the arm without an anti‐EGFR monoclonal antibody during the treatment of mCRC were included. A statistical analysis was performed with Review Manager 4.2.8. RESULTS: Seven randomized trials ( n = 4186) were identified. The pooled response rates were 25.4% and 17.6% by intention‐to‐treat analyses for patients with or without an anti‐EGFR monoclonal antibody, respectively, the OR was 3.36 (95% CI 1.42–7.95); the incidence of grades 3–4 adverse events were 71.2% and 54.3% for two groups, respectively, the OR was 2.23 (95% CI 1.74–2.86). The incidence of diarrhea, skin toxicity, hypomagnesemia was 62.3% versus 55.7%; 79.3% versus 19.7%; 27.2% versus 5.6%; and the summary OR was 1.36 (95% CI 1.03–1.80); 33.47 (95% CI 14.81–75.61); 6.73 (95% CI 3.84–11.82), respectively. CONCLUSION: Our results confirmed that monoclonal antibody targeted to EGFR could be effective in increasing response rates and could be a key therapeutic agent in the optimal treatment of mCRC, despite a moderate increase in grades 3–4 adverse events.