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Effect of a phyto‐compound on delayed gastric emptying in functional dyspepsia: A randomized‐controlled study
Author(s) -
METUGRIACHUK Yussef,
MAROTTA Francesco,
KUROI Ojime,
TSUCHIYA Junji,
GOH KheanLee,
MINELLI Emilio,
KAWAKITA Satoru.
Publication year - 2008
Publication title -
journal of digestive diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 51
eISSN - 1751-2980
pISSN - 1751-2972
DOI - 10.1111/j.1751-2980.2008.00347.x
Subject(s) - medicine , gastric emptying , gastroenterology , helicobacter pylori , breath test , meal , randomized controlled trial , stomach
OBJECTIVE: The aim of the present study was to assess the efficacy of a hydro‐alcoholic solution of a phytocompound based on Gentianae , Cinchonae , Absinthii and Cinnamomi on gastric emptying in Helicobacter pylori ‐negative dyspeptic patients. METHODS: The study group consisted of 24 patients with a diagnosis of long‐standing dismotility‐like functional dyspepsia. All patients were devoid of any major past or ongoing disease and dyspepsia‐associated diseases were excluded. After a 2‐week wash out period, the patients were randomized to a 2‐week treatment in which they were given 20 gtt of the compound 30 min before meals. At the beginning and end of the study, a gastric emptying test was performed by a paracetamol absorption test using a standard meal. The global symptom index (GSI) was assessed daily by a validated questionnaire. RESULTS: Treatment with the phytocompound significantly improved the gastric emptying test ( P < 0.01) which was delayed in dyspeptic patients as well as GSI ( P < 0.05). CONCLUSION: This phytocompound might be an effective therapeutic option in the treatment of dismotility‐like dyspepsia.