Open AccessFoetal and neonatal alloimmune thrombocytopenia (FNAIT)
Author(s) -
Husebekk A,
Skogen B,
Killie MK,
Ahlen T,
Tiller H,
Eksteen M,
Stuge T,
KjeldsenKragh J
Publication year - 2011
Publication title -
isbt science series
Language(s) - English
Resource type - Journals
eISSN - 1751-2824
pISSN - 1751-2816
DOI - 10.1111/j.1751-2824.2011.01498.x
Subject(s) - neonatal alloimmune thrombocytopenia , fetus , medicine , isoantibodies , immunology , immunization , antigen , antibody , immune system , pregnancy , platelet , obstetrics , biology , genetics
Thrombocytopenia is detected in around one percent of newborns. In otherwise healthy term newborns, thrombocytopenia is most often caused by alloantibodies transferred from the mother to the foetus. In the Caucasian populations human platelet antigen (HPA)‐1a is the most immunogenic HPA. In Japan and China antibodies in the HPA‐4 system are the most frequent cause of FNAIT. The immune response against the HPA must be understood in order to avoid immunization or prevent induction of FNAIT where mothers are already immunized.