Open AccessStem cell and cord blood transplantation – state of the art
Author(s) -
Bug G.,
Serve H.
Publication year - 2010
Publication title -
isbt science series
Language(s) - English
Resource type - Journals
eISSN - 1751-2824
pISSN - 1751-2816
DOI - 10.1111/j.1751-2824.2010.01416.x
Subject(s) - cord blood , medicine , transplantation , stem cell , hematopoietic stem cell transplantation , disease , human leukocyte antigen , intensive care medicine , umbilical cord , haematopoiesis , immunology , surgery , biology , antigen , genetics
Recent advances have broadened the application of allogeneic hematopoietic stem cell (HSC) transplantation and contributed to the continuously increasing numbers of transplantations performed worldwide. These include (1) greater utilization of reduced intensity conditioning and improvement of supportive care allowing transplantation of patients up to 70 years of age and with pre‐existing medical problems, and (2) expansion of the acceptable stem cell donor pool to unrelated cord blood HSC. Thus, selection of the particular transplant procedure should be guided by patient characteristics such as type and stage of the disease, previous therapies, age and comorbidities. HLA typing of patient and siblings at diagnosis is essential to allow the timely initiation of an unrelated donor search if needed.