Open AccessWashed/replaced (W/R)‐platelets
Author(s) -
Azuma H.,
Ikeda H.
Publication year - 2009
Publication title -
isbt science series
Language(s) - English
Resource type - Journals
eISSN - 1751-2824
pISSN - 1751-2816
DOI - 10.1111/j.1751-2824.2009.01264.x
Subject(s) - platelet , adverse effect , plasma concentration , medicine , platelet rich plasma , whole blood , blood transfusion , plasma volume , anesthesia , chemistry , pharmacology
The preventive effect of plasma‐reduction on transfusion‐related adverse reaction caused by platelet concentrate (PC) is still controversial and a consensus about how much plasma should be removed is yet to be reached. However, according to previously reported papers and survey, widely various adverse reactions are preventable by plasma‐reduced PC. Recently, a case series study of plasma‐reduced PC (washed/replaced‐PC, W/R‐PC) using new platelet additive solution (M‐sol), which can preserve platelet function longer than other additive solutions at as low as 5% plasma concentration, has been conducted in Hokkaido Red Cross Blood Center. W/R‐PCs suspended in M‐sol in the presence <20ml of plasma (approximately 5% plasma concentration) were transfused safely and eliminated a wide range of adverse reactions to conventional PC. However, platelets suspended in M‐sol with 30% plasma concentration failed to prevent the occurrence of adverse reactions. We concluded that residual plasma volume of <20ml is preferable to elicit a satisfactory preventive effect and M‐sol might make it feasible for blood center to prepare plasma‐reduced PCs (<20ml of residual plasma) and bring them to hospitals.