Open AccessUnrelated haematopoietic stem cell transplantation and bank
Author(s) -
Morishima Y.
Publication year - 2009
Publication title -
isbt science series
Language(s) - English
Resource type - Journals
eISSN - 1751-2824
pISSN - 1751-2816
DOI - 10.1111/j.1751-2824.2009.01254.x
Subject(s) - human leukocyte antigen , transplantation , immunology , stem cell , hematopoietic stem cell transplantation , haematopoiesis , permissive , disease , leukemia , biology , medicine , antigen , genetics
Allogeneic haematopoietic stem cell transplantation (HSCT) is an established treatment for a variety of haematological malignancies. Accumulating evidence indicates that genetic polymorphisms in HLA, and/or killer cell Ig‐like receptors have critical impact on immunobiological complications such as graft‐versus‐host disease, engraftment and graft‐versus‐leukemia effects. In HLA‐mismatched transplantation, identification of permissive and non‐permissive HLA alleles is crucial for increasing the number of patients who can benefit from this curative modality. This article reviews the recent tremendous progress focusing on unrelated HSCT and HLA matching.