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Antimicrobial Photodynamic Therapy and Photodynamic Inactivation, or Killing Bugs with Dyes and Light—A Symposium‐in‐Print
Author(s) -
Hamblin Michael R.
Publication year - 2012
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2012.01139.x
Subject(s) - photodynamic therapy , singlet oxygen , photosensitizer , photochemistry , antimicrobial , triplet state , singlet state , chemistry , radical , excited state , electron transfer , reactive oxygen species , oxygen , molecule , organic chemistry , biochemistry , physics , atomic physics
In antimicrobial photodynamic therapy, the photosensitizer (PS) in its ground singlet state absorbs light to give the excited singlet state that can transition to the long‐lived triplet state. This PS triplet may undergo energy transfer (Type 2) or electron transfer (Type 1) to oxygen to form reactive oxygen species (singlet oxygen and/or hydroxyl radicals) that can kill both Gram‐positive and Gram‐negative bacteria and fungi. Infections in animal models can also be treated.