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Ciprofloxacin Photosensitized Oxidation of 2′‐Deoxyguanosine‐5′‐Monophosphate in Neutral Aqueous Solution
Author(s) -
Liu Yancheng,
Zhang Peng,
Li Haixia,
Wang Wenfeng
Publication year - 2012
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2012.01092.x
Subject(s) - chemistry , flash photolysis , aqueous solution , photochemistry , reaction rate constant , redox , photodissociation , radical ion , ion , medicinal chemistry , inorganic chemistry , kinetics , organic chemistry , physics , quantum mechanics
Laser flash photolysis studies have been carried out to investigate the reactions of ciprofloxacin (CPX) with 2′‐deoxyguanosine‐5′‐monophosphate (dGMP), N , N , N ′, N ′‐tetramethyl‐ p ‐phenylenediamine (TMPD) and ferulic acid (FCA) in neutral aqueous solutions, respectively. CPX triplet state ( 3 CPX * ) can be quenched by TMPD, FCA and dGMP, with rate constants of 1.8 × 10 9 , 1.5 × 10 9 and 5.8 × 10 7 dm 3 mol −1 s −1 , respectively. TMPD radical cation (TMPD ·+ ) and FCA radical cation (FCA ·+ ) were observed directly. The formation rate of CPX radical anion (CPX ·− ) was determined to be 1.5 × 10 9 dm 3 mol −1 s −1 . Redox reaction of dGMP was investigated through competing reactions using TMPD and FCA as probe. The triplet energy of CPX was determined to be 262 kJ mol −1 . Electron transfer from TMPD, FCA and dGMP to 3 CPX * was proposed.