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Characterization of CdHgTe/CdS QDs for Near Infrared Fluorescence Imaging of Spinal Column in a Mouse Model
Author(s) -
Chen Haiyan,
Cui Sisi,
Tu Zhenzhen,
Ji Jinzi,
Zhang Jun,
Gu Yueqing
Publication year - 2010
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2010.00828.x
Subject(s) - characterization (materials science) , fluorescence , infrared , materials science , column (typography) , fluorescence lifetime imaging microscopy , nanotechnology , chemistry , optoelectronics , optics , computer science , physics , telecommunications , frame (networking)
Near infrared (NIR) CdHgTe/CdS quantum dots (QDs) were successfully prepared by a green synthetic route. The characteristics such as morphology, size, spectra, stability and toxicity were investigated in detail. The fluorescence wavelength of CdHgTe/CdS QDs could be adjusted to the NIR range (812 nm), which made the in vivo NIR imaging possible. The in vivo dynamic biodistribution of CdHgTe/CdS QDs in a mouse model was monitored by an NIR imaging system. Results indicated that CdHgTe/CdS QDs with a diameter of about 5.8 nm targeted to spinal column effectively. Further imaging of the dissected spine disclosed that QDs targeted to vertebra rather than spinal cord. The high fluorescence intensity together with targeting effect makes CdHgTe/CdS QDs particular candidates for imaging purposes in experimental animal models of vertebral injury.