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Differential Signaling Circuits in Regulation of Ultraviolet C Light‐induced Early‐ and Late‐phase Activation of NF‐κB
Author(s) -
Wu Shiyong,
Tong Lingying
Publication year - 2010
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2010.00767.x
Subject(s) - nf κb , chemistry , signal transduction , nfkb1 , phase (matter) , irradiation , microbiology and biotechnology , biophysics , transcription factor , biology , biochemistry , physics , gene , organic chemistry , nuclear physics
Ultraviolet C light (UVC) induces nuclear factor‐kappa B (NF‐κB) activation via a complex network. In the early phase (4–12 h) of irradiation, NF‐κB activation is accompanied with IκBα reduction via a translation inhibition pathway. In the late phase of UVC‐induced NF‐κB activation (16–24 h), the IκBα depletion is a combined result of regulation at both transcriptional and translational levels. However, the NF‐κB activation appears to be independent of the level of IκBα. In this review, we will discuss the multiple signaling circuits that regulate NF‐κB activation during the early and late phases of UVC irradiation.