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Photodynamic Therapy in the Treatment of Actinic Keratosis †
Author(s) -
Stritt Andrea,
Merk Hans Friedrich,
Braathen Lasse Roger,
Von Felbert Verena
Publication year - 2008
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2007.00276.x
Subject(s) - photodynamic therapy , actinic keratosis , cryotherapy , dermatology , medicine , keratosis , fluorouracil , clinical trial , oncology , surgery , chemotherapy , chemistry , organic chemistry , basal cell
The efficacy of photodynamic therapy (PDT) with 5‐aminolevulinate and methyl aminolevulinate in the treatment of actinic keratosis has been demonstrated in a large number of clinical studies over the last several years. Here, we recapitulate the major findings, comparing the various photosensitizers, light sources and therapeutic regimens, and present a retrospective analysis of 142 own cases treated with 259 PDTs. In addition, we also discuss the value of PDT in comparison with cryotherapy or 5‐fluorouracil. The efficacy and the low risk of side effects of PDT have resulted in a high patient preference in clinical trials.