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Protective Effects of an Antioxidant Derived from Serine and Vitamin B 6 on Skin Photoaging in Hairless Mice ¶
Author(s) -
Kitazawa Manabu,
Ishitsuka Yukiko,
Kobayashi Misako,
Nakano Takashi,
Iwasaki Keiji,
Sakamoto Kazutami,
Arakane Kumi,
Suzuki Tadashi,
Kligman Lorralne H.
Publication year - 2005
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.2005.tb01471.x
Subject(s) - photoaging , hairless , chemistry , antioxidant , reactive oxygen species , skin aging , biochemistry , dermatology , medicine
The generation of reactive oxygen species (ROS) by ultraviolet radiation (UVR) accelerates skin aging, which is known as photoaging. Because cutaneous iron catalyzes ROS generation, sequestering iron by chelating agents is thought to be an effective approach toward preventing photoaging. Previously, N ‐(4‐pyridoxylmethylene)‐L‐serine (PYSer) was designed as an antioxidant to suppress iron‐catalyzed ROS generation by its iron‐sequestering activity. In this study, PYSer showed protective effects against skin damage in hairless mice irradiated with ultraviolet B (UV‐B). Topical application of PYSer to the skin significantly delayed and/or decreased the visible wrinkle formation induced by chronic UV‐B irradiation. A histological study indicated that UV‐B‐induced epidermal hypertrophy and lymphocytic infiltration were suppressed by PYSer. Moreover, PYSer showed suppressive activity against the UV‐B‐induced increase in glycosaminoglycans (GAG). These results indicate that PYSer is a promising antioxidant for the prevention of chronic skin photoaging by its iron‐sequestering activity.