Premium
Enhanced Responsiveness to Photodynamic Therapy‐Induced Apoptosis after Mitochondrial DNA Depletion
Author(s) -
Kessel David,
Sun Hai Hao
Publication year - 1999
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1999.tb08305.x
Subject(s) - photodynamic therapy , mitochondrial dna , apoptosis , cisplatin , mitochondrion , cytotoxic t cell , dna damage , cancer research , biology , chemistry , microbiology and biotechnology , dna , chemotherapy , in vitro , genetics , gene , organic chemistry
Several lines of evidence indicate that mitochondria are an especially sensitive target for photodamage. Reports of cross resistance between photodynamic therapy (PDT) and the drug cisplatin, along with evidence that depletion of mitochondrial DNA (mtDNA) sensitized cells to cisplatin suggested a study of the photodynamic responsiveness of murine leukemia control L1210 cells versus cells depleted of mtDNA. Loss of mtDNA led to an increased sensitivity to mitochondrial photodamage, while the cytotoxic effects of lysosomal photodamage were not affected. Cells depleted of mtDNA showed an enhanced ap‐optotic response to PDT involving a mitochondrial target, compared with control cells.