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Singlet Oxygen Generation by Metallotexaphyrins
Author(s) -
Grossweiner Leonard I.,
Bilgin Mehmet D.,
Berdusis Peter,
Mody Tarak D.
Publication year - 1999
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1999.tb07981.x
Subject(s) - singlet oxygen , oxygen , photochemistry , chemistry , organic chemistry
. Metallotexaphyrins have clinical applications as photo‐sensitizers of photodynamic therapy (PDT). The singlet oxygen quantum yield (φ> Δ ) was determined for a series of metallotexaphyrin derivatives (Lu [III], Y [III], Cd [II], In [III] and Gd [in]) under conditions where the agents are believed to exist in monomeric form. The results show φ Δ of metallotexaphyrins vary with the medium and the metal cation. Measurements on the Lu (III) texaphyrin led to φ Δ = 0.38 in unbuffered 5% Tween 20 and φ Δ = 0.58 in pH 7.4 phosphate buffer plus 1% Triton X‐100 (±10%). The in vitro photodynamic efficiency calculated from φ Δ is compared to in vivo PDT efficacy in an animal tumor model.