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Immunosuppressive Effects of Silicon Phthalocyanine Photodynamic Therapy
Author(s) -
Reddan Julie C.,
Anderson Cathy Young,
Xu Hui,
Hrabovsky Sharon,
Freye Kristin,
Fairchild Roberta,
Tubesing Karen A.,
Elmets Craig A.
Publication year - 1999
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1999.tb01951.x
Subject(s) - photodynamic therapy , immunosuppression , photosensitizer , sensitization , cancer research , in vivo , immune system , tumor necrosis factor alpha , medicine , immunotherapy , immunity , immunology , chemistry , biology , photochemistry , microbiology and biotechnology , organic chemistry
— The purpose of this study was to determine if silicon phthalocyanine 4 (Pc 4), a second‐generation photosensitizer being evaluated for the photodynamic therapy (PDT) of solid tumors, was immunosuppressive. Mice treated with Pc 4 PDT 3 days before dinitrofluorobenzene sensitization showed significant suppression of their cell‐mediated immune response when compared to mice that were not exposed to PDT. The response was dose dependent, required both Pc 4 and light and occurred at a skin site remote from that exposed to the laser. The immunosuppression could not be reversed by in vivo pre‐treatment of mice with antibodies to tumor necrosis factor‐alpha or interleukin‐10. These results provide evidence that induction of cell‐mediated immunity is suppressed after Pc 4 PDT. Strategies that prevent PDT‐mediated immunosuppression may therefore enhance the efficacy of this therapeutic modality.