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Photophysical Studies of Some 5,10,15,20‐Tetraarylethynylporphyrinatozinc(II) Complexes as Potential Lead Compounds for Photodynamic Therapy
Author(s) -
Lacey Jackie A.,
Phillips David,
Milgrom Lionel R.,
Yahioglu Gokhan,
Rees Robert D.
Publication year - 1998
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1998.tb05170.x
Subject(s) - singlet oxygen , photodynamic therapy , quantum yield , chemistry , photochemistry , singlet state , quantum efficiency , quantum , spectral line , quantum chemical , yield (engineering) , oxygen , fluorescence , molecule , atomic physics , optoelectronics , materials science , excited state , physics , optics , organic chemistry , quantum mechanics , astronomy , metallurgy
The photophysics of 5,10,15,20‐tetraarylethynylporphyrinatozinc(II) complexes, 1 and 2, are reported. Compared to 5,10,15,20‐tetraphenylporphyrinatozinc(II) (ZnTPP), the UV/visible spectra of 1 and 2 have red‐shifted B and Q bands, with the Q bands of increased intensity relative to the B band. FIuorescence quantum yields and lifetimes and triplet quantum yields and lifetimes are similar to ZnTPP. However, quantum yields for in vitro singlet‐oxygen generation are much larger than for ZnTPP and for 2 the quantum yield is near unity. These findings suggest that the title compounds could be potential lead compounds as sensitizers for photodynamic therapy.