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Raman Spectroscopy and Fluorescence Photon Migration for Breast Cancer Diagnosis and Imaging
Author(s) -
Manoharan Ramasamy,
Shafer Karen,
Perelman Lev,
Wu Jun,
Chen Kun,
Deinum Geurt,
Fitzmaurice Maryann,
Myles Jonathan,
Crowe Joseph,
Dasarl Ramachandra R.,
Feld Michael S.
Publication year - 1998
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1998.tb05160.x
Subject(s) - raman spectroscopy , fluorescence , spectroscopy , two photon excitation microscopy , photon , breast cancer , materials science , fluorescence lifetime imaging microscopy , optics , fluorescence spectroscopy , nuclear magnetic resonance , cancer , medicine , physics , quantum mechanics
We are developing optical methods based on near infra‐red Raman spectroscopy and fluorescence photon migration for diagnosis and localization of breast cancer. We demonstrate the ability of Raman spectroscopy to classify accurately normal, benign and malignant breast tissues, an important step in developing Raman spectroscopic needle probes as a tool for improving the accuracy of needle biopsy. We also show that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick turbid medium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging.