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Identification and Quantification of Intrinsic Optical Contrast for Near‐infrared Mammography
Author(s) -
Quaresima Valentina,
Matcher Stephen J.,
Ferrari Marco
Publication year - 1998
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1998.tb05159.x
Subject(s) - transillumination , hemoglobin , mammography , contrast (vision) , near infrared spectroscopy , breast imaging , wavelength , breast tissue , spectroscopy , nuclear magnetic resonance , imaging phantom , chemistry , nuclear medicine , biomedical engineering , materials science , medicine , optics , pathology , physics , breast cancer , optoelectronics , cancer , quantum mechanics
Near‐infrared spectroscopy has been used to quantify the composition of healthy female breast tissue in vivo . By collecting transillumination spectra in the wavelength range 680–1100 nm at 7–9 positions on the breasts of five female volunteers, an attempt was made to quantify the intra‐ and intersubject variability of breast composition. The dominant absorbers are water, lipids and hemoglobin. Hemoglobin concentration in the breast is substantially lower than that in the brain or muscle (less than 10 μ M ). The measured deoxyhemoglobin concentration can vary by up to 100% between different positions on the same breast. Water and lipid concentrations can show similar variability. Phantom and simulation studies demonstrate that this variability is not due to the effects of tissue boundaries on the measurements. The low hemoglobin concentration implies that optical breast imaging should be performed at wavelengths below about 850 nm to ensure that the image contrast comes predominantly from hemoglobin. Intrasubject variability could have implications for the ability of optical imaging to discern tumors from background contrast variations.