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Effect of Magnetite Particles on Photoinduced and Nonphotoinduced Free Radical Processes in Human Erythrocytes
Author(s) -
Chignell Colin F.,
Sik Robert H.
Publication year - 1998
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1998.tb02520.x
Subject(s) - magnetite , chemistry , magnetite nanoparticles , biophysics , photochemistry , materials science , nanotechnology , biology , nanoparticle , magnetic nanoparticles , metallurgy
Magnetite (Fe 3 0 4 ) encapsulated in polystyrene microspheres dramatically decreased the time for 50% hemolysis (t 1/2 ) of human erythrocytes irradiated (λ300 nm) in the presence of ketoprofen (0.1 mM). The magnetic microspheres were present at a very low concentration (0.002%) such that on average there was only one particle per four erythrocytes. No such effect was seen when nonmagnetic microspheres were employed or when the equivalent concentration of soluble iron (FeCl 3 ) was present. A decrease in t 1/2 was also observed when the magnetic microspheres were added after UVA/ketoprofen treatment or when they were present during hemolysis initiated by thermolysis of 2,2′‐azobis(2‐amidinopro‐pane). These findings may be attributed to an increase in the membrane concentration of lipid radicals as a result of a magnetic field‐induced increase in radicals escaping from triplet radical pairs.