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Meso‐Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy
Author(s) -
Faustino Maria A. F.,
Neves Maria G. P. M. S.,
Vicente Maria G. H.,
Cavaleiro Jose A. S.,
Neumann Marcus,
Brauer HansD.,
Jori Giulio
Publication year - 1997
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1997.tb03165.x
Subject(s) - photosensitizer , tetraphenylporphyrin , porphyrin , dimer , photodynamic therapy , derivative (finance) , photochemistry , chemistry , organic chemistry , financial economics , economics
— Studies on the synthesis, preliminary in vivo biological activity, singlet oxygen and fluorescence yields of a di‐meric porphyrin (Dl) are described. The pharmacokinetic behavior and photodynamic properties of the dimer Dl were examined in Balb/c mice bearing an MS‐2 fibrosarcoma. Compound Dl shows a high selectivity for tumor localization (tumor/peritumoral tissue ratios of dye concentration ranging between ca 100 and 140 at 24 h after drug administration of 5.0‐1.0 mg kg ‐1 into DL‐AL‐dipalmitoylphosphatidylcholine liposomes). The photo‐therapeutic efficiency of dimer Dl was evaluated by following the growth curves of fibrosarcoma irradiated with red light (600‐700 nm) with a total dose of 400 J cm ‐2 , at 24 h after intravenous injection. Photodynamic therapy‐treated tumors showed a significant delay in growth as compared to untreated control mice. The results obtained suggest that the porphyrin dimer Dl may be a promising candidate for further use in PDT experiments.