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Comparative Photophysical Study of Disulfonated Aluminum Phthalocyanine in Unilamellar Vesicles and Leukemic K562 Cells
Author(s) -
Dhami Suman,
Rumbles Garry,
MacRobert Alexander J.,
Phillips David
Publication year - 1997
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1997.tb01881.x
Subject(s) - vesicle , phthalocyanine , liposome , fluorescence , phosphatidylcholine , chemistry , k562 cells , photochemistry , biophysics , membrane , biochemistry , organic chemistry , cell , biology , physics , optics , phospholipid
— The photophysical properties of cis ‐disulfonated aluminum phthalocyanine (AlPcS 2 ) in unilamellar vesicles (liposomes) of DL‐a‐dipalmitoyl‐phosphatidylcholine have been measured. Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration. The time‐resolved fluorescence decays, analyzed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS 2 in leukemic K562 cells. Information on the pho‐todynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.