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Local Photodynamic Therapy Reduces Tissue Hyperplasia in an Experimental Restenosis Model
Author(s) -
Gonschior Peter,
Gerheuser Florian,
Fleuchaus Michael,
Huehns Tanya Y.,
Goetz Alwin E.,
Welsch Ulrich,
Sroka Ronald,
Dellian Marc,
Lehr Hans A.,
Höfling Berthold
Publication year - 1996
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1996.tb01831.x
Subject(s) - photodynamic therapy , photosensitizer , restenosis , medicine , hyperplasia , angioplasty , phototoxicity , urology , lesion , surgery , pathology , radiology , chemistry , stent , in vitro , biochemistry , organic chemistry
— Local photodynamic therapy may have potential in preventing myointimal hyperplasia after angioplasty. In this study, the effect of photodynamic therapy was evaluated in an experimental model of restenosis. Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries. Animals were randomly allocated to four groups: group 1, unidirectional injury only; group 2, injury followed by local delivery of photosensitizer; group 3, injury followed by local exposure to monochromatic light; and group 4, where injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (photodynamic therapy). Seven, 14 or 21 days after treatment, all experimental vessels were excised, fixed and processed for histology. An inflammatory and myoproliferative response was observed after injury in vessels from groups 1, 2 and 3. In group 4, after injury followed by photodynamic therapy, the myoproliferative response was significantly reduced. Thus, in this study, tissue hyperplasia after unidirectional injury was effectively suppressed by photodynamic therapy.