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PHOTOSENSITIZATION AND TISSUE DISTRIBUTION STUDIES OF THE PICKET FENCE PORPHYRIN, 3,1‐TPRO, A CANDIDATE FOR PHOTODYNAMIC THERAPY
Author(s) -
Lawrence David S.,
Gibson Scott L.,
Nguyen My Lien,
Whittemore Kenneth R.,
Whitten David G.,
Hilf Russell
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb09248.x
Subject(s) - photodynamic therapy , porphyrin , clearance , chemistry , biophysics , combinatorial chemistry , photochemistry , biology , medicine , organic chemistry , urology
— From a structurally distinct set of o ‐substituted tetraphenylporphyrins, the picket fence porphyrin (PFP), 3,1‐ meso ‐tetrakis( o ‐propionamidophenyl)porphyrin (3,1‐TPro) has been selected as a potential candidate for use in the photodynamic therapy (PDT) of cancer. In this report, the time‐dependent tissue distribution of 14 C‐labeled 3,1‐TPro is described along with the results of various treatment regimens. The tissue distribution of radiolabeled 3,1‐TPro is comparable to that of other porphyrin photosensitizers with the advantage of being most effective at 4 h and being cleared rapidly from most tissues. The results of the various treatment regimen experiments, as well as other studies, indicate that the 3,1‐TPro mechanism of action is similar to that of other photosensitizers, but may include some minor differences. The conclusion is that 3,1‐TPro and other PFP offer a class of effective photosensitizers that may be exploited for their structural versatility, straightforward synthesis leading to a compound of high purity and known structure, and stability (both in terms of shelf‐life and in vivo metabolism) as potential candidates for PDT.