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EVALUATION OF NEW BENZOPORPHYRIN DERIVATIVES WITH ENHANCED PDT EFFICACY*
Author(s) -
Pandeyi Ravindra K.,
Potter William R.,
Meunier Isabelle,
Sumlin Adam B.,
Smith Kevin M.
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb08727.x
Subject(s) - phototoxicity , in vivo , chemistry , derivative (finance) , ether , photosensitizer , vinyl ether , combinatorial chemistry , stereochemistry , organic chemistry , in vitro , biochemistry , microbiology and biotechnology , copolymer , economics , financial economics , biology , polymer
— A first report on the biological evaluation of a series of isomerically pure benzoporphyrin derivatives ( cis‐ and frarcs‐isomers) as methyl esters is described. In preliminary in vivo studies, the n‐ bexyl ether analogues of both cis‐ and trans ‐isomers of benzoporphyrin derivatives were found to be more active than the industrially prepared benzoporphyrin derivative, a mixture of monocarboxylic acids (BPDMA, Quadralogic Technologies, Vancouver). Further studies with 4‐de‐vinyl‐4‐(I‐hexyloxyethyl) benzoporphyrin derivative showed that, like BPDMA, it had reduced residual skin phototoxicity compared in mice with Photofrin®. The uptake and clearance characteristics of BPDMA were also compared with the 4‐(1‐hexyloxyethyl)‐derivative by in vivo reflection spectroscopy.