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In vivo EXCITATION OF PHOTOSENSITIZERS BY INFRARED LIGHT
Author(s) -
Lenz P.
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb05277.x
Subject(s) - pheophorbide a , hematoporphyrin , fluorescence , photosensitizer , photochemistry , irradiation , chemistry , photodynamic therapy , infrared , phthalocyanine , excitation , chlorin , wavelength , absorption (acoustics) , in vivo , materials science , optoelectronics , optics , physics , electrical engineering , organic chemistry , nuclear physics , composite material , engineering , microbiology and biotechnology , biology
— Use of near infrared instead of visible light would markedly improve tissue penetration, making larger tumors candidates for photochemotherapy. Because common photosensitizers exhibit virtually no absorption in this wavelength region, conditions are required where the simultaneous action of two photons is possible. Healthy tissue (rat ears), sensitized by hematoporphyrin derivative, sulfonated chloroaluminum phthalocyanine or pheophorbide a, was irradiated (1064 nm, 10 ns) with power densities up to 200 MW cm ‐2 and total energy densities up to 200 kJ cm ‐2 . No reproducible photodynamic lesions were observed, but there was sensitizer fluorescence that depended quadratically on the excitation intensity.