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UNUSUALLY HIGH AFFINITY OF Zn(II)‐TETRADIBENZOBARRELENOOCTABUTOXY‐ PHTHALOCYANINE FOR LOW‐DENSITY LIPOPROTEINS IN A TUMOR‐BEARING MOUSE
Author(s) -
Soncin M.,
POLO L.,
REDDI E.,
JORI G.,
RIHTER B. D.,
KENNEY M. E.,
RODGERS M. A. J.
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb03977.x
Subject(s) - phthalocyanine , bearing (navigation) , chemistry , biophysics , zinc , biochemistry , biology , organic chemistry , physics , astronomy
— An important factor in determining the efficacy of photosensitizing compounds in photodynamic therapy of tumors is the level to which tumors take up the photosensitizers after systemic injection. This parameter seems to be related to the transport modalities of the photosensitizer in the bloodstream. In this work the photosensitizer Zn(II)‐tetradibenzobarreleno‐octabutoxyphthalocyanine was shown to have an unprecedentedly high association with low‐density lipoproteins (71% of the phthalocyanine in the plasma) when delivered in Cremophor micelles to tumor‐bearing mice. This was accompanied by a particularly high tumor uptake at 24 h post‐injection.