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A COMPARATIVE STUDY OF THE VISIBLE LIGHT PHOTOCHEMISTRY OF GILVOCARCINS V and M
Author(s) -
Alegria Antonio E.,
Zayas Luis,
Guevara Norberto
Publication year - 1995
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1995.tb02361.x
Subject(s) - quantum yield , singlet oxygen , chemistry , photochemistry , yield (engineering) , oxygen , nitrogen , superoxide , singlet state , ion , medicinal chemistry , organic chemistry , fluorescence , materials science , excited state , physics , quantum mechanics , nuclear physics , metallurgy , enzyme
— Quantum yields for the formation of superoxide ions, O 2 −1 , and singlet oxygen, 1 O 2 , were determined during the photolyses of gilvocarcin M (GM) in air‐saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO‐water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen‐saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.