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PHOTOCHEMICAL STABILITY OF BIOLOGICALLY ACTIVE COMPOUNDS. IX. CHARACTERIZATION OF THE SPECTROSCOPIC PROPERTIES OF THE 4‐AMINOQUINOLINES, CHLOROQUINE AND HYDROXYCHLOROQUINE, AND OF SELECTED METABOLITES BY ABSORPTION, FLUORESCENCE AND PHOSPHORESCENCE MEASUREMENTS
Author(s) -
Nord Karin,
Karlsen Jan,
Tosnnesen Hanne Worth
Publication year - 1994
Publication title -
photochemistry and photobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.818
H-Index - 131
eISSN - 1751-1097
pISSN - 0031-8655
DOI - 10.1111/j.1751-1097.1994.tb05128.x
Subject(s) - phosphorescence , aminoquinolines , fluorescence , photochemistry , chemistry , protonation , absorption (acoustics) , deprotonation , organic chemistry , combinatorial chemistry , materials science , physics , composite material , quantum mechanics , ion
The spectroscopic properties of the antimalarials chloroquine, hydroxychloroquineand selected metabolites were investigated by absorption, fluorescence and phosphorescence measurements. The antimalarials exhibit both fluorescence and phosphorescence. Fluorescence dominates for the deprotonated forms of the 4‐aminoquinolines, while phosphorescence dominates when the compounds are protonated. The phosphorescence lifetimes of the 4‐aminoquinolines were measured. Both the protonated and the deprotonated forms have long phosphorescence lifetimes indicating a long‐lived triplet state.